Antiviral activities of <i>Glycyrrhiza uralensis</i> components against Singapore grouper iridovirus

Singapore grouper iridovirus (SGIV) is a serious pathogen that negatively impacts aquaculture. Because of its 90% fatality rate, effective medications control SGIV infection are urgently needed. Glycyrrhiza uralensis well-known medicinal plant contains active ingredients with antiviral, antibacterial, and other biological activities. In this study, we evaluated the application G. components against infection. The safe working concentrations components, which were identified by light microscope observation CCK-8 detection, as follows: aqueous extract (GUF) ? 10 mg/ml, glycyrrhizin 100 ?g/ml, glycyrrhetinic acid 50 liquiritin 25 isoliquiritigenin liquiritigenin ?g/ml. did not have significant effects infection, whereas GUF showed anti-SGIV activity in concentration-dependent manner, it also destroyed structure virus particles. Therefore, might impact binding particles to cell receptors stage replication host cells. These results show extracts good great potential for treating